Ennis has since carved out a successful career in the American comics industry, notably creating the hit series Preacher (later made into a television series) and the fan favourite Hitman for DC Comics. He has also worked extensively for many other publishers including Marvel Comics, Wildstorm, Black Bull, Avatar, and Dynamite Entertainment. Something of an historian, he has a particular fondness for telling stories based in World War II.
According to 2000 AD prog 705, Ennis' favourite food is Guinness and his favourite obsession is "lunatics who make a big deal out of being Irish because of some third generation ancestry or something, and then rant constantly about it." He got started in comics because "I had to escape from the horrors of university somehow. You know something's wrong when you're wandering around the student union looking for places to hide the bodies."